HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl azetidine-3-carboxylate → 1-(2-{4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl azetidine-3-carboxylate | HCID 20132751 | — |
| Reactant | {4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid | HCID 59392514 | — |
| Solvent | NaOH dioxane | HCID 18323598 | — |
| Product | 1-(2-{4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid | HCID 59392508 | — |
Reaction Steps
1-(2-{4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid is prepared from {4-[5-(6-Isobutyl-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid and azetidine-3-carboxylic acid methyl ester in analogy to Example 55; stirring this material in 3 N aq. NaOH/dioxane at rt for 20 h gives the desired compound; LC-MS: tR=0.60, [M+1]+=434.96.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288554B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-83e44cf885c34a3198e03505c1cdfaed |
| Source note | uspto-grants-2012_10 |