2-(Dimethylamino)ethanol → HCID 2817340, compound

Temperature

0 °C

To a solution of N,N-dimethylethanolamine (890 mg, 10 mmol) and triethylamine (1520 mg, 15 mmol) in anhydrous CH2Cl2, kept under nitrogen atmosphere, at 0° C., methansulphonyl chloride (1220 mg, 11 mmol) was added. The mixture was kept under stirring and at 0° C. for 1 hour, and then concentrated by evaporation. The residue was dissolved in CH2Cl2, washed with Na2CO3 saturated solution and with deionized water. The organic phase was dried under Na2SO4 and the solvent removed by evaporation. The product was used as obtained, without purification, for the following step b) (1330 mg, yield 80%).

1. customkept under nitrogen atmosphere, at 0° C.
2. concentrationconcentrated by evaporation
3. dissolutionThe residue was dissolved in CH2Cl2
4. washwashed with Na2CO3 saturated solution and with deionized water
5. customThe organic phase was dried under Na2SO4
6. customthe solvent removed by evaporation
7. customas obtained, without purification, for the following step b) (1330 mg, yield 80%)

ORD record

ord-2eadf8aec457489d8a25ec13614edc9a

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08288528B2