Ammonia → 2-Amino-5-(trifluoromethoxy)benzonitrile
Reaktionsgleichung
Br[C:2]1[CH:8]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cu](C#N)[C:15]#[N:16].N>CN1CCCC1=O>[NH2:4][C:3]1[CH:5]=[CH:6][C:7]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:8][C:2]=1[C:15]#[N:16]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 163 °C
Versuchsvorschrift
To a solution of 2-bromo-4-(trifluoromethoxy)aniline (15.1 g, 60.0 mmol) in N-methylpyrrolidone (100 mL) was added copper cyanide (10.6 g, 118 mmol) and the reaction mixture was stirred for 6.5 h at 163° C. After cooling to ambient temperature it was poured onto ice-water (300 mL) and aqueous ammonia (350 mL). The resulting brown precipitate was collected by filtration, washed with water (150 mL) and dissolved in dichloromethane (350 mL). The insoluble material was removed by filtration and the filtrate was washed with brine (100 mL) and dried over sodium sulfate. Purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 25:75:) afforded the title compound (9.09 g, 76%) as a brown solid. MS: m/e=405.1 [2M+H]+.
Aufarbeitung
- temperatureAfter cooling to ambient temperature it
- filtrationThe resulting brown precipitate was collected by filtration
- washwashed with water (150 mL)
- dissolutiondissolved in dichloromethane (350 mL)
- customThe insoluble material was removed by filtration
- washthe filtrate was washed with brine (100 mL)
- dry with materialdried over sodium sulfate
- customPurification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 25:75:)
Quellen und Nachweise
- ORD-Eintrag
- ord-5bb35ba24bc34aa58cb14ba58c04850a
- Quelldatensatz
- uspto-grants-2012_10
- Patentnummer
- US08293730B2
Notizen zur Reaktion
Wird geladen…