Tetrahydro-4H-pyran-4-one → HCID 58054337, compound

HRID 2066413Notes

Reaction equation

HRID 2066413 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([O:12][CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:3]=1.[O:32]1[CH2:37][CH2:36][C:35](=O)[CH2:34][CH2:33]1>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([O:12][CH:13]3[CH2:18][CH2:17][N:16]([CH:35]4[CH2:36][CH2:37][O:32][CH2:33][CH2:34]4)[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:3]=1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 58054334HCID 58054334, compound

Product 1

HCID 58054337HCID 58054337, compound

Procedure

The compound was prepared from tert-butyl 4-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yloxy)piperidine-1-carboxylate following General Procedures of Boc-deprotection and reductive amination with dihydro-2H-pyran-4(3H)-one.

Sources & evidence

ORD record
ord-7f44b28af0da489d8bb183797894ddb8
Source dataset
uspto-grants-2012_10
Patent number
US08293736B2

Reaction notes

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