反应详情

To 2-chloro-5-nitro-nicotinic acid (1.0 mmol) in methanol was added a solution of sodium methoxide in methanol (2.4 mmol, freshly prepared from sodium metal in methanol). The solution was refluxed for 2 h and the mixture was allowed to cool and concentrated in vacuo. To the resulting residue was added 10% citric acid solution (20 ml) and the solution extracted with ethyl acetate (20 ml). The organic layer was dried (MgSO4) and concentrated in vacuo. The residue was crystallised from water to give a yellow-white solid (73%).

1. temperatureThe solution was refluxed for 2 h
2. temperatureto cool
3. concentrationconcentrated in vacuo
4. additionTo the resulting residue was added 10% citric acid solution (20 ml)
5. extractionthe solution extracted with ethyl acetate (20 ml)
6. dry with materialThe organic layer was dried (MgSO4)
7. concentrationconcentrated in vacuo
8. customThe residue was crystallised from water