反应详情

To a solution of 6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (1.00 g, 2.87 mmol) in DMF (20 mL) were added 1,4-dioxa-8-aza-spiro[4.5]decane (1.06 mL, 8.62 mmol) and cesium carbonate (1.8 g, 5.75 mmol). The resulting mixture was stirred at RT for 90 min. The reaction mixture was diluted with water then extracted with EtOAc. The organic extracts were dried (Na2SO4) and concentrated in vacuo to give the title compound as an orange solid (0.97 g, 82%).

1. extractionthen extracted with EtOAc
2. dry with materialThe organic extracts were dried (Na2SO4)
3. concentrationconcentrated in vacuo