(3aR,7aS)-rel-tert-Butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate → 5-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

HRID 2066486Notes

Reaction equation

HRID 2066486 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:21][CH2:20][C:15]4(OCCO4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[C:28]([O:32][C:33]([N:35]1C2C(CNCC2)[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH:15]2[CH:14]([CH2:13][N:12]([CH2:11][C:9]3[S:10][C:5]4[C:4]([N:22]5[CH2:23][CH2:24][O:25][CH2:26][CH2:27]5)=[N:3][C:2]([Cl:1])=[N:7][C:6]=4[CH:8]=3)[CH2:21][CH2:20]2)[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 49761056(3aR,7aS)-rel-tert-Butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylateHCID 581170818-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

Product 1

HCID 581170905-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 8-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane using octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester in place of 1,4-dioxa-8-aza-spiro[4.5]decane. The title compound was obtained as white solid (153 mg, 90%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d7ea03dbbee34df4bb7352fe05829293
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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