1-Cyclopropylpiperazine dihydrochloride → HCID 58117149, compound

HRID 2066494Notes

Reaction equation

HRID 2066494 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.Cl.Cl.[CH:21]1([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:22]1.ClC1N=C(N2CCOCC2)C2C=C(CN3CCN(C4CC4)CC3)SC=2N=1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:27]3[CH2:28][CH2:29][N:24]([CH:21]4[CH2:23][CH2:22]4)[CH2:25][CH2:26]3)=[CH:8][C:6]=2[N:7]=1

Participants

4

Reactant 3

HCID 212208121-Cyclopropylpiperazine dihydrochlorideHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehydeHCID 58117084HCID 58117084, compound

Product 1

HCID 58117149HCID 58117149, compoundYield 79.1%

Procedure

A mixture of 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde (254 mg) and 1-cyclopropylpiperazine di-HCl (352 mg) was reacted under the reductive amination conditions described for 2-chloro-6-(4-cyclopropyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine, to give the title compound (279 mg) as a white solid.

Workup

  1. customwas reacted under the reductive amination conditions

Sources & evidence

ORD record
ord-10a41b78d6114b4780c96271bad1e332
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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