HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropylpiperazine dihydrochloride → HCID 58117149, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropylpiperazine dihydrochloride | HCID 21220812 | — |
| Reactant | 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde | HCID 45789985 | — |
| Reactant | HCID 58117084 | HCID 58117084 | — |
| Product | HCID 58117149 | HCID 58117149 | 79.1% |
Reaction Steps
A mixture of 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde (254 mg) and 1-cyclopropylpiperazine di-HCl (352 mg) was reacted under the reductive amination conditions described for 2-chloro-6-(4-cyclopropyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine, to give the title compound (279 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-10a41b78d6114b4780c96271bad1e332 |
| Source note | uspto-grants-2012_10 |