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HRID2066501

反应详情

EQUATION

反应方程式

HRID 2066501 的结构方程式

REACTANTS

反应物

3
结构：C1CNC1
HCID10422

Azetidine

C3H7N

结构：CC(C)(C)OC(=O)N1CCC(=O)C(F)C1
HCID10560711

TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE

C10H16FNO3

结构：CN1CCC2(CC1)CNC2
HCID10997117

7-methyl-2,7-diazaspiro[3.5]nonane

C8H16N2

PRODUCTS

生成物

1
结构：F[C@@H]1CNCC[C@@H]1N1CCC1
HCID66870306

rel-(3R,4S)-4-(1-Azetidinyl)-3-fluoropiperidine

C8H15FN2

PROCEDURE

实验过程

Prepared according to the method used in the preparation of 7-methyl-2,7-diaza-spiro[3.5]nonane using 3-fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester in place of formaldehyde and azetidine in place of 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester hydrochloride. The title compound was obtained as a colourless oil (205 mg, 56%).

WORKUP

后处理

  1. customPrepared