HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine → (cis)-4-Azetidin-1-yl-3-fluoro-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate | HCID 10560711 | — |
| Reactant | 7-Methyl-2,7-diazaspiro[3.5]nonane | HCID 10997117 | — |
| Product | (cis)-4-Azetidin-1-yl-3-fluoro-piperidine | HCID 66870306 | — |
Reaction Steps
Prepared according to the method used in the preparation of 7-methyl-2,7-diaza-spiro[3.5]nonane using 3-fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester in place of formaldehyde and azetidine in place of 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester hydrochloride. The title compound was obtained as a colourless oil (205 mg, 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-0c43f9ad780d4c839cad79b70d40d5b2 |
| Source note | uspto-grants-2012_10 |