HCID 58117100, compound → (+/-)-[(trans)-4-Azetidin-1-yl-1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-methanol

HRID 2066511Notes

Reaction equation

HRID 2066511 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11]N3CC4(CCN(C)CC4)C3)=[CH:8][C:6]=2[N:7]=1.[N:28]1([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH:33]2[CH2:38][OH:39])[CH2:31][CH2:30][CH2:29]1>>[N:28]1([C@@H:32]2[CH2:37][CH2:36][N:35]([CH2:11][C:9]3[S:10][C:5]4[C:4]([N:22]5[CH2:27][CH2:26][O:25][CH2:24][CH2:23]5)=[N:3][C:2]([Cl:1])=[N:7][C:6]=4[CH:8]=3)[CH2:34][C@H:33]2[CH2:38][OH:39])[CH2:29][CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 58117100HCID 58117100, compoundHCID 66870060(4-Azetidin-1-yl-piperidin-3-yl)-methanol

Product 1

HCID 86761639(+/-)-[(trans)-4-Azetidin-1-yl-1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-methanol

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using (4-azetidin-1-yl-piperidin-3-yl)-methanol in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compounds were separated by column chromatography.

Workup

  1. customPrepared
  2. customThe title compounds were separated by column chromatography

Sources & evidence

ORD record
ord-45f384b338804d80a4739e938bf6d204
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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