HCID 58117100, compound → Thieno[3,2-d]pyrimidine, 2-chloro-6-[[4-(3,3-difluoro-1-azetidinyl)-1-piperidinyl]methyl]-4-(4-morpholinyl)-

HRID 2066519Notes

Reaction equation

HRID 2066519 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11]N3CC4(CCN(C)CC4)C3)=[CH:8][C:6]=2[N:7]=1.[F:28][C:29]1([F:39])[CH2:32][N:31]([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:30]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:36]3[CH2:35][CH2:34][CH:33]([N:31]4[CH2:32][C:29]([F:28])([F:39])[CH2:30]4)[CH2:38][CH2:37]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 58117100HCID 58117100, compoundHCID 596056804-(3,3-Difluoroazetidin-1-yl)piperidine

Product 1

HCID 58117075Thieno[3,2-d]pyrimidine, 2-chloro-6-[[4-(3,3-difluoro-1-azetidinyl)-1-piperidinyl]methyl]-4-(4-morpholinyl)-

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 4-(3,3-difluoroazetidin-1-yl)-piperidine in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (115 mg, 74%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a28a38357e7944789b112db15148e983
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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