HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58117100, compound → Thieno[3,2-d]pyrimidine, 2-chloro-6-[[4-(3,3-difluoro-1-azetidinyl)-1-piperidinyl]methyl]-4-(4-morpholinyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58117100 | HCID 58117100 | — |
| Reactant | 4-(3,3-Difluoroazetidin-1-yl)piperidine | HCID 59605680 | — |
| Product | Thieno[3,2-d]pyrimidine, 2-chloro-6-[[4-(3,3-difluoro-1-azetidinyl)-1-piperidinyl]methyl]-4-(4-morpholinyl)- | HCID 58117075 | — |
Reaction Steps
Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 4-(3,3-difluoroazetidin-1-yl)-piperidine in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (115 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a28a38357e7944789b112db15148e983 |
| Source note | uspto-grants-2012_10 |