6,9-Diazaspiro[4.5]decane dihydrochloride → 2-Chloro-6-(6,9-diaza-spiro[4.5]dec-9-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 2066520Notes

Reaction equation

HRID 2066520 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:15]C4(CCN(C)CC4)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1.Cl.Cl.[CH2:30]1[C:34]2(CNC[CH2:36][NH:35]2)[CH2:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:15][C:34]4([CH2:30][CH2:31][CH2:32][CH2:33]4)[NH:35][CH2:36][CH2:13]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 448908686,9-Diazaspiro[4.5]decane dihydrochlorideHCID 58117100HCID 58117100, compound

Product 1

HCID 581171322-Chloro-6-(6,9-diaza-spiro[4.5]dec-9-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Procedure

Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 6,9-diaza-spiro[4.5]decane dihydrochloride in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (76 mg, 53%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-10cdf59fd09e48d3abba31bb980929e9
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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