HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,9-Diazaspiro[4.5]decane dihydrochloride → 2-Chloro-6-(6,9-diaza-spiro[4.5]dec-9-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,9-Diazaspiro[4.5]decane dihydrochloride | HCID 44890868 | — |
| Reactant | HCID 58117100 | HCID 58117100 | — |
| Product | 2-Chloro-6-(6,9-diaza-spiro[4.5]dec-9-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | HCID 58117132 | — |
Reaction Steps
Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using 6,9-diaza-spiro[4.5]decane dihydrochloride in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (76 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-10cdf59fd09e48d3abba31bb980929e9 |
| Source note | uspto-grants-2012_10 |