Octahydropiperazino[2,1-c]morpholine → (+/-)-8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrazino[2,1-c][1,4]oxazine

HRID 2066528Notes

Reaction equation

HRID 2066528 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][C:14](=O)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH2:25]1[CH:30]2CNCCN2C[CH2:27][O:26]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]4[CH:14]([CH2:27][O:26][CH2:25][CH2:30]4)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 19777228Octahydropiperazino[2,1-c]morpholineHCID 866501844-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-2-one

Product 1

HCID 58117125(+/-)-8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrazino[2,1-c][1,4]oxazine

Procedure

Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]-pyrimidin-6-ylmethyl)-piperazin-2-one using octahydro-pyrazino[2,1-c][1,4]oxazine in place of piperazin-2-one. The title compound was obtained as a white solid (79 mg, 64%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3bc492f6948946d1a719024d9440b8aa
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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