HuagongsheHuagongshe Chemistry Print Report · For research reference only
Octahydropiperazino[2,1-c]morpholine → (+/-)-8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrazino[2,1-c][1,4]oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Octahydropiperazino[2,1-c]morpholine | HCID 19777228 | — |
| Reactant | 4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-2-one | HCID 86650184 | — |
| Product | (+/-)-8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrazino[2,1-c][1,4]oxazine | HCID 58117125 | — |
Reaction Steps
Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]-pyrimidin-6-ylmethyl)-piperazin-2-one using octahydro-pyrazino[2,1-c][1,4]oxazine in place of piperazin-2-one. The title compound was obtained as a white solid (79 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3bc492f6948946d1a719024d9440b8aa |
| Source note | uspto-grants-2012_10 |