(S)-octahydropyrazino[2,1-c][1,4]oxazine → HCID 58117122, compound

HRID 2066534Notes

Reaction equation

HRID 2066534 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15]C(=O)[C@@H]3C(C)C)=[CH:8][C:6]=2[N:7]=1.[CH2:28]1[C@@H:33]2[CH2:34]NCCN2[CH2:31][CH2:30][O:29]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]4[C@H:33]([CH2:28][O:29][CH2:30][CH2:31]4)[CH2:34]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 59452751(S)-octahydropyrazino[2,1-c][1,4]oxazineHCID 86650185HCID 86650185, compound

Product 1

HCID 58117122HCID 58117122, compound

Procedure

Prepared according to the method used in the preparation of (S)-4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3-isopropyl-piperazin-2-one using (5)-octahydro-pyrazino[2,1-c][1,4]oxazine in place of (S)-3-isopropyl-piperazin-2-one. The title compound was obtained as a pale yellow solid (210 mg, 90%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-16e66475e5d14609b347459ca17a1d14
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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