1-(Oxan-4-yl)piperazine → HCID 58117126, compound

HRID 2066545Notes

Reaction equation

HRID 2066545 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[Cl:13][C:14]1[N:15]=[C:16]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:17]2[S:22][C:21]([CH:23]=O)=[CH:20][C:18]=2[N:19]=1>>[Cl:13][C:14]1[N:15]=[C:16]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[C:17]2[S:22][C:21]([CH2:23][N:10]3[CH2:11][CH2:12][N:7]([CH:4]4[CH2:5][CH2:6][O:1][CH2:2][CH2:3]4)[CH2:8][CH2:9]3)=[CH:20][C:18]=2[N:19]=1

Participants

3

Reactant 2

HCID 219423151-(Oxan-4-yl)piperazineHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 58117126HCID 58117126, compound

Procedure

Prepared from 1-(tetrahydro-pyran-4-yl)-piperazine and 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde under reductive amination conditions described in Reference Example 39, to give, after silica chromatography purification, the title compound as a white solid (190 mg, 61%) [M+H]+ 439.4

Workup

  1. customto give
  2. customafter silica chromatography purification

Sources & evidence

ORD record
ord-7db005d6b2a04145a3b645c6aee4dba0
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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