2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → HCID 58117120, compound

HRID 2066546Notes

Reaction equation

HRID 2066546 reaction equation
[CH3:1][CH:2]1[CH:6]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:5][CH2:4][O:3]1.[Cl:13][C:14]1[N:15]=[C:16]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:17]2[S:22][C:21]([CH:23]=O)=[CH:20][C:18]=2[N:19]=1>>[Cl:13][C:14]1[N:15]=[C:16]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[C:17]2[S:22][C:21]([CH2:23][N:10]3[CH2:9][CH2:8][N:7]([CH:6]4[CH2:5][CH2:4][O:3][CH:2]4[CH3:1])[CH2:12][CH2:11]3)=[CH:20][C:18]=2[N:19]=1

Participants

3

Reactant 2

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehydeHCID 57586029Pentitol, 1,4-anhydro-2,3,5-trideoxy-3-(1-piperazinyl)-

Product 1

HCID 58117120HCID 58117120, compound

Procedure

1-(2-methyl-tetrahydro-furan-3-yl)-piperazine was reacted with 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde under reductive amination conditions described in Reference Example 39, to give, after silica chromatography purification the title compound as a white solid (110 mg, 43%).

Workup

  1. customto give
  2. customafter silica chromatography purification the title compound as a white solid (110 mg, 43%)

Sources & evidence

ORD record
ord-3719893d9b424563bf94a47eb46f29e1
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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