HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → HCID 58117120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde | HCID 45789985 | — |
| Reactant | Pentitol, 1,4-anhydro-2,3,5-trideoxy-3-(1-piperazinyl)- | HCID 57586029 | — |
| Product | HCID 58117120 | HCID 58117120 | — |
Reaction Steps
1-(2-methyl-tetrahydro-furan-3-yl)-piperazine was reacted with 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde under reductive amination conditions described in Reference Example 39, to give, after silica chromatography purification the title compound as a white solid (110 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293735B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3719893d9b424563bf94a47eb46f29e1 |
| Source note | uspto-grants-2012_10 |