HCID 58117149, compound → HCID 46238784, compound

HRID 2066562Notes

Reaction equation

HRID 2066562 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([CH:18]4[CH2:20][CH2:19]4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.CC1(C)C(C)(C)OB([C:35]2[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]3[C:36]=2[CH:37]=[CH:38][NH:39]3)O1>>[CH:18]1([N:15]2[CH2:16][CH2:17][N:12]([CH2:11][C:9]3[S:10][C:5]4[C:4]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)=[N:3][C:2]([C:35]5[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]6[C:36]=5[CH:37]=[CH:38][NH:39]6)=[N:7][C:6]=4[CH:8]=3)[CH2:13][CH2:14]2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 58117149HCID 58117149, compoundHCID 668820641H-Indole-6-carbonitrile, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Product 1

HCID 46238784HCID 46238784, compoundYield 21.7%

Procedure

A mixture of 2-chloro-6-(4-cyclopropyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (200 mg) and 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-H-indole-6-carbonitrile (273 mg) were reacted using Suzuki coupling method B, to give the title compound (55 mg) as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-544c0becff8145d2be1761e0e0c7d5eb
Source dataset
uspto-grants-2012_10
Patent number
US08293735B2

Reaction notes

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