HCID 66996881, compound → HCID 59344737, compound

HRID 2066580Notes

Reaction equation

HRID 2066580 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[CH2:16][CH2:15][C:14]3[C:9](=[C:10]([O:26]C)[C:11](=[O:25])[N:12]4[CH2:22][CH2:21][CH2:20][CH2:19][N:18]([CH3:23])[C:17](=[O:24])[C:13]4=3)[C:8]2=[O:28])=[CH:4][CH:3]=1>Br.C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH2:16][CH2:15][C:14]3[C:9](=[C:10]([OH:26])[C:11](=[O:25])[N:12]4[CH2:22][CH2:21][CH2:20][CH2:19][N:18]([CH3:23])[C:17](=[O:24])[C:13]4=3)[C:8]2=[O:28])=[CH:29][CH:30]=1

Participants

4

Reactant 1

HCID 66996881HCID 66996881, compound

Product 1

HCID 59344737HCID 59344737, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

A solution of 11-(4-fluorobenzyl)-9-methoxy-2-methyl-3,4,5,6,12,13-hexahydro-2H[1,4]diazocino[2,1-a]-2,6-naphthyridine-1,8,10(11H)-trione (27 mg, 0.07 mmol) in 30% hydrobromide in acetic acid was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under vacuum. The residue was concentrated from a solution in toluene twice. The resultant solid was triturated with a mixture of diethyl ether and dichloromethane to provide the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. concentrationThe residue was concentrated from a solution in toluene twice
  3. customThe resultant solid was triturated with a mixture of diethyl ether and dichloromethane

Sources & evidence

ORD record
ord-98b9e11f1fe644c09a88718f79eb3a3e
Source dataset
uspto-grants-2012_10
Patent number
US08293731B2

Reaction notes

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