HCID 131730033, compound → tert-Butyl 4-(3-aminopyridin-4-yl)piperazine-1-carboxylate

HRID 2066614Notes

Reaction equation

HRID 2066614 reaction equation
[N+]([CH:4]1[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:8][CH2:7][N:6]([C:17]2[CH:22]=[CH:21]C=CN=2)[CH2:5]1)([O-])=O>C(OCC)(=O)C.[Pd]>[C:13]([O:12][C:10]([N:9]1[CH2:4][CH2:5][N:6]([C:17]2[CH:22]=[CH:21][N:6]=[CH:5][C:4]=2[NH2:9])[CH2:7][CH2:8]1)=[O:11])([CH3:14])([CH3:15])[CH3:16]

Participants

4

Reactant 1

HCID 131730033HCID 131730033, compound

Product 1

HCID 43462405tert-Butyl 4-(3-aminopyridin-4-yl)piperazine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3-Nitro-4-boc piperizinyl pyridine was dissolved in ethyl acetate and few drops of acetic acids was added. The resulting solution was subjected Pd/C(10%, 10 mol %) and was kept under hydrogen atmosphere at room temperature. Overnight stirring and monitored the reaction progress until the reaction is complete. The reaction solution was filtered through celite and concentrated to give the product, 4-(3-Amino-pyridin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester in good yield (80%)

Workup

  1. customwas kept under hydrogen atmosphere at room temperature
  2. filtrationThe reaction solution was filtered through celite and
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-156d3a3cb2b54f05b20bd229b6eeb9cb
Source dataset
uspto-grants-2012_10
Patent number
US08293747B2

Reaction notes

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