HRID2066642
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Ring closure of alcohol 126 with NaH (1.5 equiv.) as in Example 2A for 80 min, followed by chromatography of the product on silica gel, eluting with CH2Cl2, gave 26 (97%) as a cream solid: mp (CH2Cl2/hexane) 130-131° C.; 1H NMR (CDCl3) δ 7.48 (s, 1H), 7.45-7.29 (m, 5H), 7.16 (dt, J=8.7, 2.4 Hz, 2H), 6.94 (dt, J=8.7, 2.4 Hz, 2H), 5.06 (s, 2H), 4.52 (d, J=11.7 Hz, 1H), 4.47 (d, J=11.7 Hz, 1H), 4.32 (d, J=10.0 Hz, 1H), 3.86 (d, J=10.0 Hz, 1H), 3.67 (d, J=10.6 Hz, 1H), 3.53 (d, J=10.6 Hz, 1H), 1.62 (s, 3H). Anal. (C21H21N3O5) C, H, N.
WORKUP
后处理
- customfor 80 min
- washeluting with CH2Cl2