HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl bromoacetate → Methyl 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| Product | Methyl 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetate | HCID 24849710 | — |
Reaction Steps
The title compound was prepared from methyl 2-bromoacetate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.54 (s, 1H), 8.83 (s, 2H), 7.97 (d, 1H), 7.23 (d, 1H), 4.73 (s, 2H), 4.66 (s, 1H), 3.92 (s, 3H), 3.69 (s, 3H); MS (ESI): 424.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745646B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fd321fd2741843669cb3731128632eca |
| Source note | uspto-grants-2010_06 |