Tetrahydrofuran → (9-((4-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylbenzo[d]thiazol-5-yl)methanone

HRID 206677Notes

Reaction equation

[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42](=[O:43])[c:44]4[cH:45][cH:46][c:47]5[c:48]([n:49][c:50]([CH3:52])[s:51]5)[cH:53]4)[CH2:39][CH2:40][O:41]3)[CH2:54][CH2:55]2)[s:30][cH:31]1)([CH3:23])([CH3:56])[CH3:57].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[F-:1]>>[OH:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42](=[O:43])[c:44]4[cH:45][cH:46][c:47]5[c:48]([n:49][c:50]([CH3:52])[s:51]5)[cH:53]4)[CH2:39][CH2:40][O:41]3)[CH2:54][CH2:55]2)[s:30][cH:31]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 16028Tetrabutylammonium

HCID 28179Fluoride Ion

HCID 57989353(9-((4-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylbenzo[d]thiazol-5-yl)methanone

Product 1

HCID 57989243(9-((4-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylbenzo[d]thiazol-5-yl)methanone

Sources & evidence

ORD record: ord-e65ef3705c3f4940a44d4427039745ff
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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