HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid {4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-Methyl-5-(2-(1-methylcyclopropyl)pyridin-4-yl)thiazol-2-amine | HCID 57506660 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Imidazole-1-carboxylic acid {4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}amide | HCID 86631916 | — |
Reaction Steps
A mixture of 4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-ylamine (Step 1.2) (28.5 mmol) and CDI (42.8 mmol) in CH2Cl2 (330 mL) was refluxed for 11 h. After cooling to rt, the reaction mixture was filtered to afford the title compound as a light green solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293753B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-05346c94a5234debad0105d682e982f3 |
| Source note | uspto-grants-2012_10 |