反应详情

A mixture of (1Z,4E)-1-hydroxy-5-methoxy-1-(1-methyl-cyclopropyl)-penta-1,4-dien-3-one one (Step 1.7) (111 mmol) and TFA (221 mmol) in toluene (175 mL) was stirred for 15.5 h at rt and then concentrated. The residue was purified using a RediSep® silica gel column to afford the title compound as a white solid. LC-MS: tR=1.48 min, [M+H]+ 151; TLC: Rf=0.26 (EtOAc).

1. concentrationconcentrated
2. customThe residue was purified