HCID 66851478, compound → HCID 66890967, compound

HRID 2066790Notes

Reaction equation

HRID 2066790 reaction equation
[C:1]([NH:4][CH2:5][C@@H:6]1[CH2:10][CH2:9][N:8]([C@H](C2C=CC=CC=2)C)[C@@H:7]1[C:19]([NH2:21])=[O:20])(=[O:3])[CH3:2]>[Pd].O>[C:1]([NH:4][CH2:5][C@@H:6]1[CH2:10][CH2:9][NH:8][C@@H:7]1[C:19]([NH2:21])=[O:20])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 66851478HCID 66851478, compound

Product 1

HCID 66890967HCID 66890967, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.8 but (2S,3S)-3-(acetylamino-methyl)-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Step 5.2) was used instead of (2S,3R)-3-methyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide. Moreover, 10% Pd on charcoal, wet with 50% H2O (Aldrich 330108) was used instead of the dry catalyst.

Sources & evidence

ORD record
ord-64498bd18a5c48b58ad0a7b3a213c2f1
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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