HCID 58092731, compound → HCID 58092709, compound

HRID 2066793Notes

Reaction equation

HRID 2066793 reaction equation
[N:1]1([CH2:7][C@@H:8]2[CH2:12][CH2:11][N:10]([C@H](C3C=CC=CC=3)C)[C@@H:9]2[C:21]([NH2:23])=[O:22])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>[Pd].O>[N:1]1([CH2:7][C@@H:8]2[CH2:12][CH2:11][NH:10][C@@H:9]2[C:21]([NH2:23])=[O:22])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 58092731HCID 58092731, compound

Product 1

HCID 58092709HCID 58092709, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.8 but (2S,3S)-3-morpholin-4-ylmethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Step 7.2) was used instead of (2S,3R)-3-methyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide. Moreover, 10% Pd on charcoal, wet with 50% H2O (Aldrich 330108) was used instead of the dry catalyst.

Sources & evidence

ORD record
ord-9df93ac5037e455dbd2f129d5ff13e1a
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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