反应详情

HCl (1.17 g 32% aqueous solution) was added to a solution of N-[4′-methyl-2-(1-trifluoromethyl-cyclopropyl)-[4,5′]bithiazolyl-2′-yl]-acetamide (Step 10.3) (0.18 g) in EtOH (10 mL) and the reaction mixture heated at reflux for 7 h. The cooled reaction mixture was partitioned between EtOAc and aqueous NaHCO3 solution, the organic layers dried over Na2SO4 and evaporated to give the title compound. MS (ESI): positive 306.1 (M+H), negative 304.1 (M−H).

1. temperaturethe reaction mixture heated
2. temperatureat reflux for 7 h
3. customThe cooled reaction mixture
4. customwas partitioned between EtOAc and aqueous NaHCO3 solution
5. dry with materialthe organic layers dried over Na2SO4
6. customevaporated