Hydrochloric Acid → HCID 58095730, compound

HRID 2066797Notes

Reaction equation

HRID 2066797 reaction equation
Cl.[CH3:2][C:3]1[N:4]=[C:5]([NH:20]C(=O)C)[S:6][C:7]=1[C:8]1[N:9]=[C:10]([C:13]2([C:16]([F:19])([F:18])[F:17])[CH2:15][CH2:14]2)[S:11][CH:12]=1>CCO>[CH3:2][C:3]1[N:4]=[C:5]([NH2:20])[S:6][C:7]=1[C:8]1[N:9]=[C:10]([C:13]2([C:16]([F:19])([F:18])[F:17])[CH2:14][CH2:15]2)[S:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86649582HCID 86649582, compound

Product 1

HCID 58095730HCID 58095730, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

HCl (1.17 g 32% aqueous solution) was added to a solution of N-[4′-methyl-2-(1-trifluoromethyl-cyclopropyl)-[4,5′]bithiazolyl-2′-yl]-acetamide (Step 10.3) (0.18 g) in EtOH (10 mL) and the reaction mixture heated at reflux for 7 h. The cooled reaction mixture was partitioned between EtOAc and aqueous NaHCO3 solution, the organic layers dried over Na2SO4 and evaporated to give the title compound. MS (ESI): positive 306.1 (M+H), negative 304.1 (M−H).

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for 7 h
  3. customThe cooled reaction mixture
  4. customwas partitioned between EtOAc and aqueous NaHCO3 solution
  5. dry with materialthe organic layers dried over Na2SO4
  6. customevaporated

Sources & evidence

ORD record
ord-6ba4be43f7d246b28a856a1349659a3a
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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