反应详情

To a solution of N-[5-(2-bromo-acetyl)-4-methyl-thiazol-2-yl]-acetamide (0.29 g, prepared as described in WO 2005/068444) in MeOH (15 mL) at rt was added 1-trifluoromethyl-cyclopropanecarbothioic acid amide [871913-36-9] (0.20 g) and ammoniumphosphomolybdate (0.15 g). After stirring 18 h at rt, the reaction mixture was partitioned between EtOAc and water, the organic layers dried over Na2SO4 and evaporated to give the crude product. Purification by flash chromatography with an eluent of 1% MeOH in CH2Cl2 gave the title compound. MS (ESI): positive 348.1 (M+H), negative 346.1 (M−H).

1. customthe reaction mixture was partitioned between EtOAc and water
2. dry with materialthe organic layers dried over Na2SO4
3. customevaporated
4. customto give the crude product
5. customPurification by flash chromatography with an eluent of 1% MeOH in CH2Cl2