N-[5-(bromoacetyl)-4-methyl-1,3-thiazol-2-yl]acetamide → HCID 86649582, compound

Participants

Reaction Steps

To a solution of N-[5-(2-bromo-acetyl)-4-methyl-thiazol-2-yl]-acetamide (0.29 g, prepared as described in WO 2005/068444) in MeOH (15 mL) at rt was added 1-trifluoromethyl-cyclopropanecarbothioic acid amide [871913-36-9] (0.20 g) and ammoniumphosphomolybdate (0.15 g). After stirring 18 h at rt, the reaction mixture was partitioned between EtOAc and water, the organic layers dried over Na2SO4 and evaporated to give the crude product. Purification by flash chromatography with an eluent of 1% MeOH in CH2Cl2 gave the title compound. MS (ESI): positive 348.1 (M+H), negative 346.1 (M−H).

Provenance & Evidence