HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2066871Generated: October 30, 2026
Tetrahydrofuran → 3,6-Dichloro-5-[4-(1-isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-pyrazine-2-carboxylic acid
https://huagongshe.com/reaction/2066871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3,6-Dichloro-5-[4-(1-isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-pyrazine-2-carboxylic acid methyl ester | HCID 86655013 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3,6-Dichloro-5-[4-(1-isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-pyrazine-2-carboxylic acid | HCID 86655014 | — |
Reaction Steps
The crude 56b obtained in the previous step was taken up with THF (1 mL) and 1N NaOH (1 mL) and heated to 50° C. for 3 h. The mixture was cooled, diluted with 5 mL of 1N HCl and extracted with EtOAc (3×5 mL). The combined extracts were dried and concentrate to afford 0.13 g of crude 56c. 25 mg of this material was purified by preparative HPLC to afford 56c: LC-MS 474.7 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08293729B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-8ec9111020314120bbd02763cb88bce1 |
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| Source note | uspto-grants-2012_10 |
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