反应详情

温度

50 °C

The crude 56b obtained in the previous step was taken up with THF (1 mL) and 1N NaOH (1 mL) and heated to 50° C. for 3 h. The mixture was cooled, diluted with 5 mL of 1N HCl and extracted with EtOAc (3×5 mL). The combined extracts were dried and concentrate to afford 0.13 g of crude 56c. 25 mg of this material was purified by preparative HPLC to afford 56c: LC-MS 474.7 (MH+).

1. temperatureThe mixture was cooled
2. extractionextracted with EtOAc (3×5 mL)
3. customThe combined extracts were dried
4. concentrationconcentrate