HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2066874Generated: October 31, 2026
Tetrahydrofuran → 2-[4-(1-Isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-4-trifluoromethyl-pyrimidine-5-carboxylic acid
https://huagongshe.com/reaction/2066874
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[4-(1-Isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester | HCID 86655015 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-[4-(1-Isopropoxycarbonyl-piperidin-4-yloxyimino)-piperidin-1-yl]-4-trifluoromethyl-pyrimidine-5-carboxylic acid | HCID 86655016 | — |
Reaction Steps
The crude 57a obtained in the previous step was taken up with THF (3 mL) and 1N NaOH (0.6 mL) and heated to 50° C. for 2 h. The mixture was cooled, diluted with 10 mL of 1N HCl and extracted with DCM (3×5 mL). The combined extracts were dried and concentrate to afford the crude 57b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08293729B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-fc704f14dd4544c3bfc6c5180a261381 |
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| Source note | uspto-grants-2012_10 |
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