反应详情

温度

50 °C

The crude 57a obtained in the previous step was taken up with THF (3 mL) and 1N NaOH (0.6 mL) and heated to 50° C. for 2 h. The mixture was cooled, diluted with 10 mL of 1N HCl and extracted with DCM (3×5 mL). The combined extracts were dried and concentrate to afford the crude 57b.

1. temperatureThe mixture was cooled
2. extractionextracted with DCM (3×5 mL)
3. customThe combined extracts were dried
4. concentrationconcentrate