Carbonic acid, cyclobutyl 4-nitrophenyl ester → HCID 58333505, compound

HRID 2066888Notes

Reaction equation

HRID 2066888 reaction equation
[N+](C1C=CC(O[C:11](=[O:17])[O:12][CH:13]2[CH2:16][CH2:15][CH2:14]2)=CC=1)([O-])=O.[NH:18]1[CH2:23][CH2:22][CH:21]([O:24][N:25]=[C:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([S:38]([CH3:41])(=[O:40])=[O:39])=[CH:34][C:33]=3[F:42])[CH2:28][CH2:27]2)[CH2:20][CH2:19]1>C(Cl)Cl>[CH:13]1([O:12][C:11]([N:18]2[CH2:23][CH2:22][CH:21]([O:24][N:25]=[C:26]3[CH2:31][CH2:30][N:29]([C:32]4[CH:37]=[CH:36][C:35]([S:38]([CH3:41])(=[O:39])=[O:40])=[CH:34][C:33]=4[F:42])[CH2:28][CH2:27]3)[CH2:20][CH2:19]2)=[O:17])[CH2:14][CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 22708352Carbonic acid, cyclobutyl 4-nitrophenyl esterHCID 866550221-(2-Fluoro-4-methanesulfonyl-phenyl)-piperidin-4-one O-piperidin-4-yl-oxime

Product 1

HCID 58333505HCID 58333505, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the reaction mixture of 64a obtained above was added 63a (30 mg, 0.08 mmol) in 0.3 mL of DCM. The mixture was stirred at room temperature for 2 h, concentrated and purified on preparative HPLC to give 64-1: LC-MS 468.4 (MH+).

Workup

  1. customobtained
  2. concentrationconcentrated
  3. custompurified on preparative HPLC
  4. customto give 64-1

Sources & evidence

ORD record
ord-dc13bcc3bd574d0098be753dc1d91163
Source dataset
uspto-grants-2012_10
Patent number
US08293729B2

Reaction notes

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