反应详情

To a solution of 4-piperidinone (2.5 mmol) in 25 mL of DCM, was added 69b (0.43 g, 2 mmol). The mixture was stirred at room temperature for 2 h. NaOAc (0.27 g, 2 mmol) and ethanol (10 mL) were added and the reaction mixture was heated at 70° C. for 2 h. The solution was allowed to cool down to room temperature and the ethanol was evaporated. The residue was extracted with ethyl acetate, washed with water, dried and concentrated to give 0.59 g of 69c.

1. temperaturethe reaction mixture was heated at 70° C. for 2 h
2. temperatureto cool down to room temperature
3. customthe ethanol was evaporated
4. extractionThe residue was extracted with ethyl acetate
5. washwashed with water
6. customdried
7. concentrationconcentrated