Trifluoroacetic acid → HCID 86655030, compound

HRID 2066904Notes

Reaction equation

HRID 2066904 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][C:8]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[CH2:20][CH2:19][C:18](=[N:21][O:22][CH:23]3[CH2:28][CH2:27][N:26]([C:29]4[N:34]=[CH:33][C:32]([CH2:35][CH3:36])=[CH:31][N:30]=4)[CH2:25][CH2:24]3)[CH2:17][CH2:16]2)=[CH:10][C:9]=1[F:37])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:35]([C:32]1[CH:31]=[N:30][C:29]([N:26]2[CH2:25][CH2:24][CH:23]([O:22][N:21]=[C:18]3[CH2:19][CH2:20][N:15]([C:11]4[C:12]([F:14])=[CH:13][C:8]([CH2:7][C:6]([OH:38])=[O:5])=[C:9]([F:37])[CH:10]=4)[CH2:16][CH2:17]3)[CH2:28][CH2:27]2)=[N:34][CH:33]=1)[CH3:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86655031HCID 86655031, compound

Product 1

HCID 86655030HCID 86655030, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 77d (141 mg) was dissolved in DCM (2 mL) and TFA (2 mL) and stirred at r.t. for 1 h. The solvent was removed in vacuo, DCM and 1M HCl were added and the organic phase was separated, dried over MgSO4 and concentrated to give (4-{4-[1-(5-Ethyl-pyrimidin-2-yl)-piperidin-4-yloxyimino]-piperidin-1-yl}-2,5-difluoro-phenyl)-acetic acid 77e (126 mg).

Workup

  1. customThe solvent was removed in vacuo, DCM and 1M HCl
  2. additionwere added
  3. customthe organic phase was separated
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c369228274d44451808a4d9bee16735d
Source dataset
uspto-grants-2012_10
Patent number
US08293729B2

Reaction notes

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