反应详情

温度

85 °C

To a suspension of 5-bromoisoquinoline (200 mg, 0.96 mmol), benzhydrylidene-hydrazine (189 mg, 0.96 mmol), palladium diacetate (2.2 mg, 0.0096 mmol) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP, 6 mg, 0.0096 mmol) in dry toluene (1 mL), sodium tert-butoxide (130 mg, 1.34 mmol) was added and the mixture was heated at 85° C. for 4 hours. The mixture, cooled to room temperature, was filtered over celite and the pad was washed with diethylether. The solvent was evaporated under vacuum and the residue was purified by flash chromatography with hexane/ethylacetate 7/3 as eluant, affording 268 mg of the title compound (86% yield).

1. additionwas added
2. temperatureThe mixture, cooled to room temperature
3. filtrationwas filtered over celite
4. washthe pad was washed with diethylether
5. customThe solvent was evaporated under vacuum
6. customthe residue was purified by flash chromatography with hexane/ethylacetate 7/3 as eluant