反应详情

2-benzyl-N,N-dimethyl-4-phenyl-2′,3′,4′,9′-tetrahydrospiro[cyclohexane-1,1′-pyrido[3,4-b]indole]-4-amine (one of 4 possible racemic diastereoisomer pairs, 62 mg, 0.14 mmol) was dissolved in 2-propanol (3 ml) in the boiling heat and mixed with a hot solution of citric acid [40 mg, 0.2 mmol, in hot isopropanol (1 ml)]. A precipitate separated out immediately. The batch was left 2 h at 5° C. to complete the precipitation, then the solid was separated by means of a fritted glass filter and dried.

1. temperatureboiling heat
2. customA precipitate separated out immediately
3. customthe precipitation
4. customthe solid was separated by means of a fritted glass
5. filtrationfilter
6. customdried