Sodium Bicarbonate → HCID 178522298, compound

HRID 2066969Notes

Reaction equation

HRID 2066969 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]([NH:16][C:17](=[O:26])[C:18]3[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:25])=[CH:14][NH:13][N:12]=2)=[O:10])[CH2:4][CH2:3]1.C(=O)(O)[O-].[Na+]>O>[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]([NH:16][C:17](=[O:26])[C:18]3[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:25])=[CH:14][NH:13][N:12]=2)=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 1784797184-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride

Product 1

HCID 178522298HCID 178522298, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide hydrochloride salt (20.6 g, 50 mmol) in water (500 ml) stirring at ambient temperature was added sodium bicarbonate (4.5 g, 53.5 mmol). The mixture was stirred for 1 hour and the solid formed collected by filtration and dried in vacuo azeotroping with toluene (×3) to give the corresponding free base of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide.

Workup

  1. customthe solid formed
  2. filtrationcollected by filtration
  3. customdried in vacuo
  4. customazeotroping with toluene (×3)

Sources & evidence

ORD record
ord-360ecc17e38b4c50bf6f724d00e8cb28
Source dataset
uspto-grants-2012_10
Patent number
US08293767B2

Reaction notes

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