反应详情

温度

65 °C

A suspension of 8-(4-cyclopropyl-2-fluoro-phenylamino)-imidazo[1,5-a]pyridine-7-carboxylic acid methyl ester (0.28 g, 0.86 mmol) and 1M NaOH (1.03 mL, 1.03 mmol) in IMS (5 mL) was heated to 65° C. for 5 hours. The reaction mixture was then cooled to room temperature and 1M HCl was added to adjust pH to 2. The precipitate formed was filtered off and dried in a drying pistol at 40° C. for 18 hours to afford the title compound as a cream solid (0.22 g, 81%). LCMS (method B): RT=2.84 min, [M+H]+=312.

1. temperatureThe reaction mixture was then cooled to room temperature
2. customThe precipitate formed
3. filtrationwas filtered off
4. customdried in a drying pistol at 40° C. for 18 hours