4-Cyclobutyl-2-fluoro-1-nitrobenzene → HCID 59565186, Verbindung

HRID 2067030Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2067030
[CH:1]1([C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([F:14])[CH:6]=2)[CH2:4][CH2:3][CH2:2]1.[H][H]>[Pd]>[CH:1]1([C:5]2[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([F:14])[CH:6]=2)[CH2:2][CH2:3][CH2:4]1

Komponenten

4

Edukt 2

HCID 595652084-Cyclobutyl-2-fluoro-1-nitrobenzeneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 59565186HCID 59565186, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A solution of 4-cyclobutyl-2-fluoro-nitrobenzene (0.5 g, 2.6 mmol) in IMS (5 mL) was degassed with argon for 2 minutes, before 10% Pd/C (0.05 g) was added, and a balloon of hydrogen affixed. The resultant mixture was stirred for 18 hours at room temperature, before being flushed with nitrogen and filtered through hyflo®. The filtrate was concentrated in vacuo to afford the title compound as an orange/red oil (0.31 g, 74%). 1H NMR (CDCl3): 6.84 (1H, d, J=12.3 Hz), 6.77 (1H, d, J=8.1 Hz), 6.70 (1H, t, J=9.1 Hz), 3.58 (2H, broad), 3.42 (1H, m), 2.28 (2H, m), 2.01 (3H, m), 1.82 (1H, m).

Aufarbeitung

  1. additionwas added
  2. custombefore being flushed with nitrogen
  3. filtrationfiltered through hyflo®
  4. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8d250690321b40e1a867f4d6dfaddb63
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08293763B2

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