HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 11612479, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone | HCID 11706669 | — |
| Reactant | Water ethylacetate | HCID 22728543 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11612479 | HCID 11612479 | — |
Reaction Steps
A solution of compound 101 (350 mg, 0.63 mmol) in methanol (4.0 mL) was added toluene-4-sulfonic acid (60 mg, 0.32 mmol) and the mixture was stirred for 7 h at RT. The reaction mixture was poured into a mixture of EtOAc/water. The organic phase was washed with NaOH (aq., 2 M), water, brine and then dried (MgSO4), filtered and concentrated in vacuo to give the crude product. The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 25:75 as the eluent to afford the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08293772B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-39bd8f6a395f499c891b72f4a987f157 |
| Source note | uspto-grants-2012_10 |