(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanone

HRID 2067214Notes

Reaction equation

HRID 2067214 reaction equation
NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1.[Cl:29][C:30]1[CH:35]=[C:34]([NH:36][C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=2[Cl:44])[CH:33]=[CH:32][C:31]=1[C:45]([C:47]1[CH:52]=[C:51]([N+:53]([O-])=O)[CH:50]=[CH:49][C:48]=1[CH3:56])=[O:46]>>[NH2:53][C:51]1[CH:50]=[CH:49][C:48]([CH3:56])=[C:47]([C:45]([C:31]2[CH:32]=[CH:33][C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=3[Cl:44])=[CH:35][C:30]=2[Cl:29])=[O:46])[CH:52]=1

Participants

3

Reactant 2

HCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanoneHCID 68421804[2-Chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone

Product 1

HCID 68417005(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 415, using compound 420 (0.21 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-337986a815d34ef688e20f3f85fbbdee
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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