(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanone → (5-Azido-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanone

HRID 2067215Notes

Reaction equation

HRID 2067215 reaction equation
[N:1](C1C=CC(C)=C(C(C2C=CC(NC3C=CC(C(F)(F)F)=CC=3)=CC=2Cl)=O)C=1)=[N+:2]=[N-].[NH2:31][C:32]1[CH:33]=[CH:34][C:35]([CH3:56])=[C:36]([C:38]([C:40]2[CH:45]=[CH:44][C:43]([NH:46][C:47]3[CH:52]=[CH:51][C:50]([F:53])=[CH:49][C:48]=3[Cl:54])=[CH:42][C:41]=2[Cl:55])=[O:39])[CH:37]=1>>[N:31]([C:32]1[CH:33]=[CH:34][C:35]([CH3:56])=[C:36]([C:38]([C:40]2[CH:45]=[CH:44][C:43]([NH:46][C:47]3[CH:52]=[CH:51][C:50]([F:53])=[CH:49][C:48]=3[Cl:54])=[CH:42][C:41]=2[Cl:55])=[O:39])[CH:37]=1)=[N+:1]=[N-:2]

Participants

3

Reactant 2

HCID 68417005(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanoneHCID 86605524(5-Azido-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

Product 1

HCID 86605525(5-Azido-2-methyl-phenyl)-[2-chloro-4-(2-chloro-4-fluoro-phenylamino)-phenyl]-methanone

Procedure

The reaction was carried out similarly as described in the preparation of compound 416, using compound 421 (0.21 mmol). The crude product was used without any further purification.

Workup

  1. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-f2771d981c9c4f2eaf61a1aba756376d
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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